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Optimizing Mobile Phase Solvent Purity for LC-MS

Mobile Phase Liquid Chrom
Credit: iStock

Liquid chromatography mass spectrometry (LC-MS) plays a pivotal role in the precise analysis of trace molecules. To enhance sensitivity and accuracy, it is crucial for researchers to upgrade from HPLC-grade solvents to LC-MS grade solvents that are specially designed to meet the stringent requirements of modern LC-MS systems.

This whitepaper compares these solvents from seven vendors across four LC-MS systems, addressing factors like baseline noise, UV impurities, signal intensity, contamination and metal ion content. 

Download this whitepaper to discover how LC-MS-grade solvents can :

  • Reduce baseline noise and UV impurities
  • Improve signal intensity for target analytes
  • Outperform competitors in terms of contamination control to ensure reliable and reproducible chromatography
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