Particle Characterization with Dynamic Image Analysis
Higher resolution, lower detection limit, and better reproducibility: that is what Dynamic Image Analysis offers the next generation of size analysis instruments. This white paper outlines how the method works, and shows application examples from typical granulation processes. Pros and cons compared to established methods, like sieving and laser diffraction, are discussed.
Traditionally, particle size distribution analysis of pharmaceutical powders and granules is carried out by sieve analysis, microscopy or with laser diffraction. These methods are established in the pharmacopoeia and used routinely in pharmaceutical laboratories all over the world.
With the introduction of Dynamic Image Analysis (DIA) as an alternative method, it is now possible to measure particle sizes >1 micron of powders, granules, pellets and suspensions as well as particle shape. A number of trials clearly demonstrate the advantages of DIA compared to the established particle sizing methods. In addition to particle size analysis with very high resolution, image analysis provides important information about the particle shape. Many pharmaceutical companies have already recognized the potential of this method, and added this instrumentation to their research and quality control labs, for example for the analysis of multi-particulate dosage forms.
