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High magnification micrograph of microglia cells stained with Rio-Hortega's method (silver carbonate). This type is the ramified or resting microglia that appears in normal brain tissue.
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Mobilizing Microglia in the Fight Against Alzheimer’s Disease

Recently approved Alzheimer's drugs work by tagging amyloid plaques for clearance by the brain's microglia. Washington University School of Medicine in St. Louis researchers are developing an alternative approach, using a homemade antibody to directly mobilize microglia.
An elderly man having a vaccine.
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What Happens to the Human Body After 200 Vaccines?

Last month a story about a 62-year-old male made headlines after he claimed to have received 217 vaccines against SARS-CoV-2. Scientists invited the individual for tests to investigate what happens in the body of a hypervaccinated individual.
T-cells.
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Immune System Involvement in Dermatomyositis Revealed

A mouse model has helped scientists uncover the biological mechanisms behind the autoimmune condition dermatomyositis.
Protein structure.
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Protein That Controls CAR T-Cell Longevity Identified

In a new study, researchers have found that a protein called FOXO1 improves the survival and function of CAR T cells, which may lead to more effective CAR T cell therapies and could potentially expand its use in difficult-to-treat cancers.
Orange and white pills spill from a prescription bottle.
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Researchers Decode the Mechanism of Action of Hepatitis B and D Virus Inhibitor

The molecular mechanisms behind the action of the hepatitis B and D virus inhibitor bulevirtide have been revealed, potentially paving the way to more targeted treatments.
A strand of RNA.
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Language Model Reads the Genome and Designs More Effective mRNA Vaccines

Language models can be used to home in on partial genome sequences and optimize those sequences to study biology and improve medicine, and have designed more effective mRNA vaccines.
Vaccine vials.
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Experimental Pancreatic Cancer Vaccine May Elicit Lasting Immune Response

New Phase 1 data from Memorial Sloan Kettering Cancer Center shows an investigational cancer vaccine may elicit lasting immune response in patients with pancreatic cancer.
A person wrapped in a blanket takes prescription pills.
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UTI Oral Vaccine Offers Promising Alternative to Antibiotics

An oral vaccine against recurrent UTIs could reduce the need for antibiotic treatment.
A stool sample.
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Stool Transplant Improves Motor Function in Parkinson's Disease Patients

Fecal microbiota transplantation improves motor symptoms in Parkinson’s disease patients after 12 months. That's according to data from the GUT-PARFECT trial that recruited 46 Parkinson's disease patient.
Doctor administering a vaccination into a patients arm
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T-Cell Deficiency in Older Adults Impacts Vaccination Response

A study has found older adults’ weaker immune response can be attributed to their relative deficiency in a specific type of T cell. This deficiency has been shown to account for poorer vaccination responses in the older population.
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