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“VEGAS” Technique Could Lead to New Scientific Tools and Treatments
The technique, dubbed VEGAS, works in mammalian cells and can yield useful new molecules within days, providing scientist with a powerful new research tool and a potential route to better therapeutics for various diseases.
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Bacteria Act as Trojan Horse to Deliver Cancer Immunotherapy
Researchers have engineered a strain of non-pathogenic bacteria that can colonize solid tumors in mice and safely deliver potent immunotherapies; this novel method could be used to locally prime tumors and stimulate the immune system to seek out difficult-to-treat tumors.
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More HPV Vaccinations Could Prevent Cancer in 1,300 Californians
Based on a 2017 rate of vaccination against HPV among a group of California 20-year-olds, researchers estimate that the group is at risk for an excess of 1,352 cases of cancer that could be prevented with a 99.5% vaccination rate.
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CRISPR Scissors Get Stuck
Researchers have found that the “scissors” component of CRISPR/Cas9 sometimes gets stuck, and that Cas9, an enzyme that cuts DNA, can also block gene activity without doing any cutting.
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New Route Transports Administered Antibodies into Lymph Nodes in Seconds
Researchers have discovered in an experimental model that a new mechanism allows the antibodies to enter the lymph node directly.
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Herceptin–Chemotherapy Drug Combo Keeps Women’s Breast Cancers at Bay
Guiding chemotherapy to a tumor by attaching it to the antibody-based target drug trastuzumab is effective at treating women with breast cancer who have no other treatment options, a new clinical trial shows.
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Genetically Manipulated Virus Destroys Tumor Cells in Mouse Model
Researchers have succeeded in using a genetically manipulated virus to destroy tumor cells upon injection into mice with prostate cancer.
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Pathogen Engineered to Self-Destruct Underlies Cancer Vaccine Platform
A team of investigators has developed a cancer vaccine technology using live, attenuated pathogens as vectors.
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Replenishing Gut Bacteria in Mice Protects Against Food Allergies
After identifying altered gut microbiota in young mice with food allergies; an oral therapy was found to replenish bacteria, which also prevented food allergy and suppressed the established disease.
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Understanding Immune Cell Recruitment Key to STI Vaccine Development
In a study published in Nature Communications, researchers from King’s have shown how skin vaccination can generate protective CD8 T-cells that are recruited to the genital tissues and could be used as a vaccination strategy for sexually transmitted infections.
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