We've updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience. You can read our Cookie Policy here.

Advertisement
mRNA Regenerates Bone Without Side Effects in Mouse Study
News

mRNA Regenerates Bone Without Side Effects in Mouse Study

mRNA Regenerates Bone Without Side Effects in Mouse Study
News

mRNA Regenerates Bone Without Side Effects in Mouse Study

Read time:
 

Want a FREE PDF version of This News Story?

Complete the form below and we will email you a PDF version of "mRNA Regenerates Bone Without Side Effects in Mouse Study"

First Name*
Last Name*
Email Address*
Country*
Company Type*
Job Function*
Would you like to receive further email communication from Technology Networks?

Technology Networks Ltd. needs the contact information you provide to us to contact you about our products and services. You may unsubscribe from these communications at any time. For information on how to unsubscribe, as well as our privacy practices and commitment to protecting your privacy, check out our Privacy Policy

Although fractures normally heal, bone will not regenerate under several circumstances. When bone does not regenerate, major clinical problems could result, including amputation.


To enhance the regeneration of bone, the Food and Drug Administration (FDA) approved recombinant human bone morphogenetic protein-2, or BMP-2. However, it is expensive and only moderately effective. It also produces side effects ― some severe.


Researchers at Mayo Clinic, along with colleagues in the Netherlands and Germany, may have a viable, less risky alternative: messenger RNA. This well-known platform for vaccines has already proven to be safe in human use by the FDA.


The findings in a study involving rats are published in Science Advances. These findings show that messenger RNA can be used at low doses to regenerate bone without side effects. Moreover, the quality of the new bone is superior to bone formed by BMP-2. The researchers also say that messenger RNA is a good choice for bone regeneration because it may not need repeat doses. Findings showed the new tissue growth that occurred after applying messenger RNA was biomechanically superior to the alternative method and remained so throughout eight weeks of monitoring.


Human bone develops in one of two ways: direct formation of bone cells from mesenchymal progenitor cells, or through endochondral ossification, in which cartilage forms first and then coverts to bone. The BMP-2 therapy uses the former method, and the messenger RNA approach uses the latter. In general, the researchers say their work proves that this method "can heal large, critical-sized, segmental osseous defects of long bones in a superior fashion to its recombinant protein counterpart."


The researchers say these findings in rats are limited, and studies are needed in large animals before any translation can be considered for clinical trials.


Reference: De La Vega Rodolfo E., van Griensven Martijn, Zhang Wen, et al. Efficient healing of large osseous segmental defects using optimized chemically modified messenger RNA encoding BMP-2. Sci Adv. 8(7):eabl6242. doi: 10.1126/sciadv.abl6242.


This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.

Advertisement