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Latest Posters


Accelerating mRNA-Based Therapy Development

The diversity of potential mRNA-based therapies has led to increased interest in using synthetic mRNA as a tool in the treatment of multiple diseases. Nevertheless, obtaining larger quantities of synthetic mRNA for clinical treatment remains a challenge.

Streamlining Biologics Development With the Expi Expression Systems

Biologics-based medicines is a rapidly growing field and a promising solution to address many unmet medical needs. Biopharmaceutical developers are actively looking for more efficient and robust production platforms to reduce timelines and overall development costs. Gibco™ Expi™ Expression Systems are complete platforms that can speed up biologics development.

Young Adult Women’s Relationship Status and HPV Risk Perceptions: A Barrier to HPV Vaccination?

Human papillomavirus (HPV) vaccine rates continue to be low in the United States. Young women ages 18-26 years are eligible for catch-up vaccination but previous research shows that relationships status and percieved risk may be barriers to HPV vaccination. The purpose of this quantitative study was to assess the association between relationship status and perceived risk for HPV among young adult women.

Bioluminescent Kinase Profiling Systems for Characterizing Small Molecule Kinase Inhibitors

In order to profile compounds against a broad panel of kinases, in-house profiling requires rigorous kinase assay development.

Pyroptosis Detection via Multiplexing Cell Death and Bioluminescent Caspase-1 Activity Assessments

Researchers developed a convenient method to confirm pyroptosis. Inflammasome activation triggers rapid pyroptosis. Preventing pyroptosis may shift form of cell death

Optimized Workflow for Single Cell Copy Number Profiling Using High Resolution Oligo CGH Arrays

Here we describe GenetiSure Pre-Screen, a same day, cost-effective, analysis workflow that combines whole genome amplification (WGA) with copy number (CN) profiling using high-resolution oligo CGH microarrays.

Touching BACE. How Inhibiting β-Amyloid Production by Steric Hindrance with a Novel Immunotherapy Improves Memory in PDAPP Mice

The work presented in this poster aims to assess whether intracerebroventricular (ICV) administration of 2B3 alleviated age dependent memory deficits in PDAPP mice and to determine whether 2B3 altered APP metabolism and NMDA receptor phosphorylation ex vivo.

Multiplexed Cell- and Bead-based Assays in a No-wash Format for Biologics Screening and Characterization

Here we present the results generated from multiplexed no-wash protocols using TTP Labtech’s mirrorball, a laser scanning cytometer.

Quantitative Cell-Based Bioassays for Individual and Combination Immune Checkpoint Immunotherapy Targets

Immune checkpoint receptors are promising new immunotherapy
targets for the treatment of a variety of diseases including cancer and
autoimmune-mediated disorders. We developed a suite of cell-based
bioluminescent reporter bioassays for individual and combination
immune checkpoint immunotherapy targets including: PD-1 (PD-L1 or PD-L2), CTLA-4, LAG-3, TIGIT, PD-1+TIGIT, GITR, 4-1BB, CD40, and OX40.

Reporter Bioassays to Assess Therapeutic Antibodies for Immunotherapy Programs

Immunotherapy, also called biologic therapy or biotherapy, stimulates certain parts of the immune system to fight diseases such as cancer. Important drug targets in immunotherapy include: Co-inhibitory receptors, such as PD-1/PD-L1, CTLA-4, LAG3, Tim3; and co-stimulatory receptors, such as GITR, CD40, OX40, 4-1BB.
Current approaches to assaying these targets are cumbersome and variable. Here we offer an improved in vitro bioassay approach.